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The concomitant administration in the protease inhibitor ritonavir considerably improves serum concentrations of sildenafil (eleven-fold increase in AUC). If VIAGRA is prescribed to patients having ritonavir, caution really should be used. Details from topics subjected to large systemic amounts of sildenafil are restricted.
Pregnancy. It's not recognized if or how sildenafil could have an impact on pregnancy or harm an unborn little one. Inform your Health care supplier if you are or strategy to be pregnant.
You may have a headache immediately after having Viagra. Problems were being Just about the most prevalent Unintended effects in scientific studies in the drug.
If you want aid remembering to acquire your dose of Viagra ahead of sex, consider environment an alarm or downloading a reminder app. Or inquire your companion to remind you to take your dose about an hour right before intercourse.
The signify constant state quantity of distribution (Vss) for sildenafil is one hundred and five L, indicating distribution to the tissues. Sildenafil and its main circulating N-desmethyl metabolite are both about ninety six% bound to plasma proteins. Protein binding is independent of complete drug concentrations.
Just after either oral or intravenous administration, sildenafil is excreted as metabolites predominantly in the feces (about eighty% of administered oral dose) and also to a lesser extent in the urine (about thirteen% from the administered oral dose).
In scientific tests with healthful volunteers of single doses up to 800 mg, adverse reactions have been comparable to Those people viewed at lower doses but incidence costs and severities were greater.
Allergic response. For those who’ve experienced an allergic response to Viagra or any of its substances, your doctor received’t prescribe Viagra.
Regardless that this complete dosage developed plasma sildenafil concentrations which were somewhere around two to 5 moments bigger in comparison to the imply greatest plasma concentrations next a single oral dose of a hundred mg in healthful male volunteers, the hemodynamic response to exercising was preserved in these people.
In case you’re enthusiastic about understanding more about OTC items that can be used in lieu of Viagra, see this text.
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In many people, the drug is best about one hour immediately check here after it’s taken. Eventually, Viagra is bit by bit removed from the human body. So about the following couple of several hours immediately after it’s taken, the drug might not perform also.
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